ncRNA name | hsa-miR-34a |
ncRNA Category | miRNA |
Disease name | age-related macular degeneration (AMD) |
Species | Homo sapiens |
Tissues/Cell_line | retinas |
Methods | transfection, microarray, RT-PCR, Western blot, LED-Northern blot, luciferase reporter assay |
Expression pattern | up-regulated |
Functional description | Up-regulation of a microglial-enriched NF-кB-sensitive miRNA-34a coupled to a down-regulation of TREM2 in the same samples. Bioinformatics/transfection-luciferase reporter assays indicated that miRNA-34a targets the 299 nucleotide TREM2-mRNA-3'UTR, resulting in TREM2 down-regulation. |
PubMed ID | 26949937 |
Year | 2016 |
Title | microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration. |
Drug-related ncRNA | NO |
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